We seek a highly motivated postdoctoral fellow in Surface Chemistry/ Biochemistry in the Kim laboratory at Western Kentucky University. Our research focuses primarily on developing novel molecular sensing technology to detect pathogens, biomarkers for common disease, and antibiotic resistance genes. We utilize DNA-binding proteins and nanomaterials for sequence-specific DNA diagnostic applications (Analyst, 2018, 143(17):4009-4016, https://www.ncbi.nlm.nih.gov/pubmed/30043772, and Nucleic Acids Research, 2011, 39(5): e29, http://nar.oxfordjournals.org/content/39/5/e29.short). This is a temporary position that is annually renewable based on satisfactory performance and funding continuation.
The rapid and sensitive detection of DNA presents a great interest and need for an increasing number of biomedical research and diagnostic applications. We are developing a novel molecular tool with the potential to revolutionize biosensor systems for pathogen and cancer biomarker detection. The use of sequence-specific DNA-binding proteins provides a powerful scaffold for 'direct' reading of specific DNA sequence. DNA-binding domains such as zinc fingers (ZFs) and novel transcriptional activator-like effectors (TALEs) are engineered as diagnostic probes. We are developing new surfaces for proteins to be immobilized, including the investigation of nanomaterials to be used for protein immobilization. We also seek to investigate protein-DNA interactions in greater detail. To this end, we probe DNA recognition and binding behaviors of the DNA-binding proteins. Job Requirements:
Applicants must hold a recent Ph.D. with a strong background in Surface Chemistry, Nanomaterials, and Biochemistry. Experience in cloning, chemical conjugation, nanomaterials, and protein biochemistry is required. Applicants with experience in surface fabrication, ZF and TALE nucleases/CRISPR-cas system, pathogenic bacteria, and cancer biomarker are strongly encouraged to apply. Excellent communication skills, including command of manuscript writing and the capacity to interact with other lab members are essential. Additional Information:
Expected Salary: $36,000-$40,000
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