Skip to main content
Skip to main content

WKU News

Too much sugar can lead to heart failure

A single sugar molecule stresses the heart and changes the muscle proteins, resulting in poor pump function leading to heart failure, U.S. researchers say.

Dr. Heinrich Taegtmeyer, principal investigator and professor of cardiology at the University of Texas Health Science Center at Houston, said the glucose metabolite glucose 6-phosphate could accumulate from eating too much starch and/or sugar.

Taegtmeyer performed pre-clinical trials in animal models, as well as tests on tissue taken from patients at the Texas Heart Institute who had a piece of the heart muscle removed to implant a left ventricle assist device by Dr. O.H. "Bud" Frazier and his team. Both led to the discovery of the damage caused by glucose metabolite glucose 6-phosphate, the study said.

"When the heart muscle is already stressed from high blood pressure or other diseases, and then takes in too much glucose, it adds insult to injury," Taegtmeyer said.

The study opened doors to possible new treatments. Two drugs, rapamycin -- an immunosuppressant -- and metformin, a diabetes medication, disrupt signaling of glucose metabolite glucose 6-phosphate and improved cardiac power in small animal studies.

"These drugs have a potential for treatment and this has now cleared a path to future studies with patients," Taegtmeyer said.

The findings were published in the Journal of the American Heart Association



Original source: http://www.upi.com/Health_News/2013/06/14/Study-Too-much-sugar-can-lead-to-heart-failure/UPI-88961371251026/#ixzz2WTq2QTrI

Categories
All News  Now Viewing Category: All
Media Relations
President Caboni News
CEBS
CHHS News
Gordon Ford College of Business
Ogden News
PCAL
Academic Affairs
WKU Regional Campuses
Glasgow News
Etown & Fort Knox
Owensboro News
Transportation
The Gatton Academy of Mathematics and Science in Kentucky
The Center for Gifted Studies
Police
Emergency Preparedness
Facilities
Housing & Residence Life
Student Activities and Organizations
Augenstein Alumni Center
Campus Activities Board
The Confucius Institute
Cultural Enhancement Series
DELO News
Department of Music
Department of Theatre & Dance
Development and Alumni Relations
Downing Museum
Downing Student Union
Employee Wellness
Hardin Planetarium
Health Services
Human Resources News
Instruments of American Excellence
International Student Office
Kinesiology, Recreation & Sport
Library News
Math News
Office of International Programs
Office of Research
Office of Sustainability
Parent's Association
School of Journalism & Broadcasting
Student Financial Assistance
Scholarships Student Financial Assistance
Student Employment
Student Government Association News
Student Research Council
Study Abroad
Van Meter Auditorium
WellU
WKU Educational Leadership Doctoral Program News
WKU Joint Admissions
WKU Parent and Family Weekend
Latest Headlines
WKU President Caboni visits Glasgow, honors area students

Western Kentucky University President Timothy C. Caboni was honored during a welcome reception at WKU-Glasgow Wednesday afternoon.

WKU's student publications finalists in all 4 Pacemaker categories

For the first time, WKU Student Publications has four finalists for national Pacemaker awards -- one in each category in which the Associated Collegiate Press honors the nation's best student-run publications.

Estate gift to support several areas on WKU campus

WKU has received an estate gift of more than $2.5 million from the late Beulah R. Winchel.

Featured Articles
Estate gift to support several areas on WKU campus

WKU has received an estate gift of more than $2.5 million from the late Beulah R. Winchel.

WKU Police Department to debut new uniforms

The WKU Police Department will be sporting a new look on Saturday afternoon (Sept. 23).

Kappa Delta Sorority to formally receive national honor Sept. 23

The WKU chapter of Kappa Delta Sorority will have plenty to celebrate Sept. 23 as it formally receives Kappa Delta’s highest honor for a collegiate chapter. The award presentation will begin at 11 a.m. at the chapter house, 1600 Chestnut St.

Note: documents in Portable Document Format (PDF) require Adobe Acrobat Reader 5.0 or higher to view,
download Adobe Acrobat Reader.

Note: documents in Excel format (XLS) require Microsoft Viewer,
download excel.

Note: documents in Word format (DOC) require Microsoft Viewer,
download word.

Note: documents in Powerpoint format (PPT) require Microsoft Viewer,
download powerpoint.

Note: documents in Quicktime Movie format [MOV] require Apple Quicktime,
download quicktime.

 
 Last Modified 5/2/17