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Dr. Blairanne Williams
Office: TCCW 322
CHEM 105 Fundamentals of Gen Chem
CHEM 106 Lab Fundamentals of General Chem
CHEM 116 Introduction to College Chemistry
Cytotoxicity of metals in mammalian cells and the biochemical interactions that regulate the cell death.
In the United States, there are three generations of FDA approved platinum based chemotherapeutics currently in use; each having a unique structure and targeting a specific type of cancer. How do these different structural components impact the cell type specific toxicity of these drugs? There are three main components to this question: how do metals enter the cell (uptake)? Are the metals retained in the cell or lost (efflux)? And lastly, what is the mechanism of cell death? Using a mammalian cell culture system, we are examining these three components of cell toxicity to better understand the biochemistry and molecular signaling components.
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