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Exercise Science Staff - Lee Winchester

Lee Winchester, Ph.D.

Lee Winchester, Ph.D.

Assistant Professor of Exercise Science

Office:  Smith Stadium East 1074A
Phone:  (270) 745-4930


PhD: University of Louisville

M.S.: University of Louisville (Physiology and Biophysics)

M.S.: University of Louisville (Exercise Physiology)

B.A.: Purdue University




EXS 122: Foundations of Kinesiology

EXS 223: Health Related Fitness-Exercise Science

EXS 296: Practicum in Exercise Science

EXS 310: Kinesiology

EXS 311: Physiology of Exercise

EXS 412: Exercise Testing and Presript

EXS 498: Capstone Res Exp Exercise Science

KIN 599: Thesis Research/Writing


Selected publications: 

Winchester, L., Veeranki, S., Pushpakumar, S., & Tyagi, S.C., Exercise Mitigates the Effects of Hyperhomocysteinemia on Adverse Skeletal Muscle Remodeling.  Awaiting Review. 2015.

Winchester, L., Veeranki, S., & Tyagi, S.C., Homocystiene Elicits an M1 Phenotype in Murine Macrophages Through an EMMPRIN Mediated Pathway. Canadian Journal of Physiology and Pharmacology. 2015, Mar 31:1-8.

Givvimani, S., Kundu, S., Pushpakumar, S., Doyle, V., Narayanan, N., Winchester, L., Veeranki, S., & Metreveli, N. Hyperhomocysteinemia: a Missing Link to Dysfunctional HDL via Paraoxanase-1. Canadian Journal of Physiology and Pharmacology. 2015 Apr 15:1-9. 

Veeranki, S., Winchester, L., & Tyagi, S.C. Hyperhomocysteinemia (HHcy) associated skeletal muscle weakness involves mitochondrial dysfunction and epigenetic modifications. Biochimica et Biophysica Acta. 2015 May;1852(5):732-41.

Winchester, L., Veeranki, S., Givvimani, S., & Tyagi, S.C. Exercise mitigates the adverse effects of hyperhomocysteinemia on macrophages, MMP-9, skeletal muscle, and white adipocytes. Canadian Journal of Physiology and Pharmacology. 2014 Jul;92(7):575-82    

Lambert, C.P., Winchester, L., Jacks, D.A., & Nader, P.A. Sex Differences in Time to Fatigue at 100% VO2 peak When Normalized for Fat Free Mass. Research in Sports Medicine: An International Journal. 2013; 21(1): 78-89.


Pearson RC, Winchester L, Olenick A, Johnson J, Shaker N, Blankenship M, OregonE,HooverD,&MaplesJM.EffectsofanAcuteHighFatLoadon Peripheral Blood Mononuclear Cell Response Among Women. Poster presented at Experimental Biology April 2017; Chicago, IL.

Pearson RC, Johnson J, Winchester L, Olenick A, Shaker N, Blankenship M, Oregon E, Hoover D, & Maples JM. The Effects of a High Fat Diet on Gene Expression in Lean and Obese Women. Poster presented at the 2017 Kentucky Physiological Society Meeting; Bowling Green, KY

Exercise Reverses the Effects of Hyperhomocysteinemia on Adverse Vascular andSkeletalMuscleRemodeling. June2016.OralPosterSession.National American College of Sports Medicine Annual Meeting.

Effects of Caffeine Supplementation on Self-Selected Treadmill Velocity. Olenick A., Green, JM., Eastep, C., Winchester, L., February 2016. Poster Session. Southeast ACSM Conference. Greenville, SC

Exercise and Diabetes: An Undervalued Intervention for Disease Prevention and Reversal. Lee J. Winchester. April 2016. College of Health and Human Services Oral Podium Presentation, Western Kentucky University

Exercise Mitigates the Deleterious Effects of Hyperhomocysteinemia on Muscular Function and Inflammation. Lee J. Winchester, MS, Sudhakar Veeranki, PhD, Sathnur Pushpakumar, MD, PhD, Srikanth Givvimani, MD, PhD, and Suresh C. Tyagi, PhD. September 2014. ACSM Integrative Physiology of Exercise Conference. Miami Beach, FL.

Reversing Increased M1/M2 Macrophage Ratio in Hyperhomocysteinemic Skeletal Muscle With Exercise. Lee J Winchester, MS, Sudhakar Veeranki, PhD, Sathnur Pushpakumar, M.D., Ph.D., and Suresh C. Tyagi, PhD. April 2014. Experimental Biology Conference. San Diego, CA.

Reversing Hyperhomocysteinemia Induced Skeletal Muscle Myopathy With Regular Exercise. Lee J Winchester, Sudhakar Veeranki and Suresh C. Tyagi. March 2014. Kentucky Physiological Society Annual Meeting. Louisville, KY

Induction of Ferritin by Small Molecules may Have Cytoprotective Effects. Winchester, L., Trent, J., Lamont, G., & Eaton, J.W. October 2013.James Graham Brown Cancer Center Retreat, University of Louisville Louisville, KY.


National Science Foundation, Kentucky NSF EPSCoR, June 2017, (Submitted for Review) I have applied for a NSF grant for a total budget of $63,440.00 that would support a proposed project on Blood Flow Restriction walk training in the elderly. The purpose of this project is to investigate the efficacy of BFR training for enhancing mobility in the older adult population and examine its effects on monocyte and neutrophil activation.

National Science Foundation: Major Research Instrumentation grant, NSF, January 2017 (submitted for review) I have applied for the Major Research Instrumentation grant through the NSF for a total grant budget of $315,357.00 with the intent of acquiring a Philips EP Q 7G 3D ultrasound imaging system for the WKU exercise physiology laboratory.

Research and Creative Activities Program Grant, Western Kentucky University, April 2016 I was awarded the internal Research and Creative Activities Program Grant from Western Kentucky University. It was awarded in the amount of $15,996.00 and is being used to fund my current research project investigating the impact of highintensity functional training on monocyte phenotype in type II diabetics.

CHHS Quick Turn-Around Grant, Western Kentucky University, November 2015 I was awarded the Quick Turn-Around Grant from the College of Health and Human Services at Western Kentucky University. It was awarded in the amount of $3,000.00 and was intended to serve as seed money for new start-up projects.


President of the Kentucky Chapter of the American Physiological Society, March 2017 - Present

College of Health and Human Services Representative of the Research and Creative Activity Program Review Committee; Western Kentucky University, November 2016 - Present

Committee Member of the College of Health and Human Services Strategic Plan Outreach Subcommittee; Western Kentucky University, February 2017 - Present

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 Last Modified 3/9/15