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Exercise Science Staff - Lee Winchester

Lee Winchester, Ph.D.

Lee Winchester, Ph.D.

Assistant Professor of Exercise Science

Office:  Smith Stadium East 1074A
Phone:  (270) 745-4930


EXS 122: Foundations of Kinesiology
EXS 223: Health Related Fitness-Exercise Science
EXS 296: Practicum in Exercise Science
EXS 310: Kinesiology


Research interest: Impact of exercise on the epigenetics of skeletal muscle, changes in inflammatory profile of the skeletal muscle tissue due to type II diabetes and pre-diabetes, and the phenotypic alterations to circulating monocytes and skeletal muscle macrophages due to type II diabetes and pre-diabetes.

Selected publications:

Winchester, L., Veeranki, S., Pushpakumar, S., & Tyagi, S.C., Exercise Mitigates the Effects of Hyperhomocysteinemia on Adverse Skeletal Muscle Remodeling.  Awaiting Review. 2015.

Winchester, L., Veeranki, S., & Tyagi, S.C., Homocystiene Elicits an M1 Phenotype in Murine Macrophages Through an EMMPRIN Mediated Pathway. Canadian Journal of Physiology and Pharmacology. 2015, Mar 31:1-8.

Givvimani, S., Kundu, S., Pushpakumar, S., Doyle, V., Narayanan, N., Winchester, L., Veeranki, S., & Metreveli, N. Hyperhomocysteinemia: a Missing Link to Dysfunctional HDL via Paraoxanase-1. Canadian Journal of Physiology and Pharmacology. 2015 Apr 15:1-9.

Veeranki, S., Winchester, L., & Tyagi, S.C. Hyperhomocysteinemia (HHcy) associated skeletal muscle weakness involves mitochondrial dysfunction and epigenetic modifications. Biochimica et Biophysica Acta. 2015 May;1852(5):732-41.

Winchester, L., Veeranki, S., Givvimani, S., & Tyagi, S.C. Exercise mitigates the adverse effects of hyperhomocysteinemia on macrophages, MMP-9, skeletal muscle, and white adipocytes. Canadian Journal of Physiology and Pharmacology. 2014 Jul;92(7):575-82    

Lambert, C.P., Winchester, L., Jacks, D.A., & Nader, P.A. Sex Differences in Time to Fatigue at 100% VO2 peak When Normalized for Fat Free Mass. Research in Sports Medicine: An International Journal. 2013; 21(1): 78-89.

Topp, R., Winchester, L. J., Sannes, S. H., Mink, A. M., Kaufman, J. S., & Jacks, D. E. A Comparison of Ice with 3.5% Menthol Gel on Blood Flow and Muscle Strength of the Lower Arm.  Journal of Sport Rehabilitation.  2011; 20: 355-366.

Topp, R., Winchester, L. J, Schilero, J. & Jacks, D. E. Effect of Topical Menthol on Ipsilateral and Contralateral Superficial Blood Flow Following a Bout of Maximum Voluntary Muscle Contraction. International Journal of Sports Physical Therapy, 2011 Jun: 6(2): 83-91.

Selected presentations:  

Exercise Mitigates the Deleterious Effects of Hyperhomocysteinemia on Muscular Function and Inflammation. Lee J. Winchester, MS, Sudhakar Veeranki, PhD, Sathnur Pushpakumar, MD, PhD, Srikanth Givvimani, MD, PhD, and Suresh C. Tyagi, PhD. September 2014. ACSM Integrative Physiology of Exercise Conference. Miami, FL.

Reversing Increased M1/M2 Macrophage Ratio in Hyperhomocysteinemic Skeletal Muscle With Exercise.  Lee J Winchester, MS, Sudhakar Veeranki, PhD, Sathnur Pushpakumar, M.D., Ph.D., and Suresh C. Tyagi, PhD. April 2014. Experimental Biology Conference. San Diego, CA.

Reversing Hyperhomocysteinemia Induced Skeletal Muscle Myopathy With Regular Exercise. Lee J Winchester, Sudhakar Veeranki and Suresh C. Tyagi. March 2014. Kentucky Physiological Society Annual Meeting. Louisville, KY

Induction of Ferritin by Small Molecules may Have Cytoprotective Effects. Winchester, L., Trent, J., Lamont, G., & Eaton, J.W.  October 2013.  James Graham Brown Cancer Center Retreat, University of Louisville Louisville, KY.



Ph.D:  Physiology and Biophysics, University of Louisville School of Medicine. 2015
M.S:  Physiology and Biophysics, University of Louisville School of Medicine. 2013
M.S: Exercise Physiology, University of Louisville 2010
B.A:  Health and Kinesiology/Health Promotion, Purdue University 2008

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 Last Modified 3/9/15