Too much sugar can lead to heart failure
|Author: Mustafa Zahmak (from United Press International---UPI)|
Date: Tuesday, June 18th, 2013
A single sugar molecule stresses the heart and changes the muscle proteins, resulting in poor pump function leading to heart failure, U.S. researchers say.
Dr. Heinrich Taegtmeyer, principal investigator and professor of cardiology at the University of Texas Health Science Center at Houston, said the glucose metabolite glucose 6-phosphate could accumulate from eating too much starch and/or sugar.
Taegtmeyer performed pre-clinical trials in animal models, as well as tests on tissue taken from patients at the Texas Heart Institute who had a piece of the heart muscle removed to implant a left ventricle assist device by Dr. O.H. "Bud" Frazier and his team. Both led to the discovery of the damage caused by glucose metabolite glucose 6-phosphate, the study said.
"When the heart muscle is already stressed from high blood pressure or other diseases, and then takes in too much glucose, it adds insult to injury," Taegtmeyer said.
The study opened doors to possible new treatments. Two drugs, rapamycin -- an immunosuppressant -- and metformin, a diabetes medication, disrupt signaling of glucose metabolite glucose 6-phosphate and improved cardiac power in small animal studies.
"These drugs have a potential for treatment and this has now cleared a path to future studies with patients," Taegtmeyer said.
The findings were published in the Journal of the American Heart Association
- All Categories
- CHHS October 2011 E-Newsletter
- CHHS November 2011 E-Newsletter
- CHHS December 2011 E-Newsletter
- CHHS January 2012 E-Newsletter
- CHHS February 2012 E-Newsletter
- CHHS March 2012 E-Newsletter
- CHHS April 2012 E-Newsletter
- CHHS May 2012 E-Newsletter
- CHHS June 2012 E-Newsletter
- CHHS July 2012 E-Newsletter
- CHHS August 2012 E-Newsletter
- CHHS September 2012 E-Newsletter
- CHHS October 2012 E-Newsletter
- CHHS November 2012 E-Newsletter
- CHHS December 2012 E-Newsletter
- CHHS January 2013 E-Newsletter
- CHHS February 2013 E-Newsletter
- CHHS March 2013 E-Newsletter
- CHHS April 2013 E-Newsletter
- CHHS May/June 2013 E-Newsletter
- CHHS July 2013 E-Newsletter
- Archived CHHS News
- CHHS October 2013 E-Newsletter
- CHHS November 2013 E-Newsletter
- CHHS September 2011 E-Newsletter
- CHHS August 2011 E-Newsletter
- CHHS July 2011 E-Newsletter
- CHHS June 2011 E-Newsletter
- CHHS May 2011 E-Newsletter
12/12 and 12/13
Saturday, December 14th
Journalism Scholars Day, a 41-year tradition at WKU, attracted more than 385 Kentucky high school journalism students from 15 schools across the state to campus on Nov. 15.
The Fall Super Saturdays program, which is put on by The Center for Gifted Studies, hosted more than 500 first through eighth graders from two states and more than 40 school districts each Saturday from Nov. 2 to Nov. 23.