Western Kentucky University

Media Relations

Too much sugar can lead to heart failure

A single sugar molecule stresses the heart and changes the muscle proteins, resulting in poor pump function leading to heart failure, U.S. researchers say.

Dr. Heinrich Taegtmeyer, principal investigator and professor of cardiology at the University of Texas Health Science Center at Houston, said the glucose metabolite glucose 6-phosphate could accumulate from eating too much starch and/or sugar.

Taegtmeyer performed pre-clinical trials in animal models, as well as tests on tissue taken from patients at the Texas Heart Institute who had a piece of the heart muscle removed to implant a left ventricle assist device by Dr. O.H. "Bud" Frazier and his team. Both led to the discovery of the damage caused by glucose metabolite glucose 6-phosphate, the study said.

"When the heart muscle is already stressed from high blood pressure or other diseases, and then takes in too much glucose, it adds insult to injury," Taegtmeyer said.

The study opened doors to possible new treatments. Two drugs, rapamycin -- an immunosuppressant -- and metformin, a diabetes medication, disrupt signaling of glucose metabolite glucose 6-phosphate and improved cardiac power in small animal studies.

"These drugs have a potential for treatment and this has now cleared a path to future studies with patients," Taegtmeyer said.

The findings were published in the Journal of the American Heart Association



Original source: http://www.upi.com/Health_News/2013/06/14/Study-Too-much-sugar-can-lead-to-heart-failure/UPI-88961371251026/#ixzz2WTq2QTrI

Categories
All News  Now Viewing Category: All
School of Journalism & Broadcasting
CEBS
Media Relations
Academic Affairs
Augenstein Alumni Center
Instruments of American Excellence
Transportation
Emergency Preparedness
Police
Department of Music
Department of Theatre & Dance
Library News
Office of Sustainability
Office of International Programs
Office of Research
Ogden News
PCAL
WKU Greeks News
WKU Parent and Family Weekend
Parent's Association
Student Activities and Organizations
Scholarships Student Financial Assistance
Student Government Association News
Van Meter Auditorium
Teaching News
Study Abroad
Student Research Council
Student Employment
WKU Joint Admissions
International Student Office
Human Resources News
Cultural Enhancement Series
CHHS News
The Confucius Institute
Campus Activities Board
GFCB
WellU
The Carol Martin Gatton Academy of Mathematics and Science in Kentucky
Development and Alumni Relations
Downing Student Union
Health Services
Hardin Planetarium
News from The Center for Gifted Studies
Student Financial Assistance
Downing Museum
Etown & Fort Knox
Facilities
Employee Wellness
Latest Headlines
PTS Closed Wednesday July 23

Call 270-745-2361 or assistance.

Sixty Campers Attend 3rd Year of The Summer Camp

The Center for Gifted Studies at Western Kentucky University recently hosted 60 campers who attended The Summer Camp from July 14 to July 18.

Housing Premium Permits SOLD OUT

Add Your Name to the Wait List

Featured Articles
Sixty Campers Attend 3rd Year of The Summer Camp

The Center for Gifted Studies at Western Kentucky University recently hosted 60 campers who attended The Summer Camp from July 14 to July 18.

31st Year of VAMPY at WKU Hosts 217 Students

The Summer Program for Verbally and Mathematically Precocious Youth (VAMPY) hosted 217 students for the three-week program from June 22 to July 12.

166 Students Come to the 32nd Year of SCATS at WKU

The Center for Gifted Studies at WKU hosted 166 campers for the 32nd annual Summer Camp for Academically Talented Middle School Students (SCATS) from June 8 to 20.

 Last Modified 7/23/13