HPV vaccine found safe in large study
|Author: By Frederik Joelving|
Date: Monday, October 1st, 2012
|Return to Archive|
(Reuters Health) - A study of nearly 190,000 young women injected with Merck & Co's human papillomavirus vaccine Gardasil found no new safety concerns.
Researchers said the only side effects they observed - rare cases of skin infections and fainting - were benign and expected.
"This analysis was very reassuring," said lead researcher Dr. Nicola Klein of the Kaiser Permanente Vaccine Study Center in Oakland, California, whose work was funded by Merck.
HPV vaccination is recommended for both boys and girls to shield them from the sexually transmitted infection, which may cause various types of cancer.
While Gardasil has already been deemed safe and effective by health regulators across the globe, large follow-up studies are typically required after vaccines hit the market to make sure less-common side effects haven't been missed.
Klein's team studied girls and women ages 9 to 26 who had had at least one Gardasil shot between 2006 and 2008. Based on electronic records, they compared ER visits and hospitalizations soon after vaccination and several months later, when short-term side effects would no longer be expected to show up.
Three doses of Gardasil, the recommended amount, cost about $360. U.S. health regulators have found no serious side effects apart from soreness at the injection site.
At first glance, several health conditions appeared to be linked to the vaccination, including seizures, allergic reactions and birth defects in vaccine recipients.
A special safety committee without ties to Merck concluded that most of these conditions were not truly caused by the vaccine, however, but rather unrelated or preexisting conditions detected when the shot was given.
"All of a sudden these things get brought up again," said Klein, "but it has absolutely nothing to do with the vaccination."
After reviewing medical records for a number of different conditions that might be linked to the vaccine, the researchers determined that only two of them were legitimate findings.
In the two weeks after getting the vaccine, there were 1.8 cases of skin infections per 10,000 women, compared to just one case per two weeks per 10,000 women months away from the vaccination.
And some of those "infections" might simply have been red swellings at the injection site, said Klein, whose findings are published in the Archives of Pediatrics & Adolescent Medicine.
A STRESS REACTION?
On the day of the vaccination, the rate of fainting was six times higher than usual. But again, the risk was very low and has been seen before in other vaccine studies, Klein said.
It's possible that fainting may be a stress reaction to the injection itself, according to Dr. Michael Brady, an expert in pediatric infectious diseases at Nationwide Children's Hospital in Columbus, Ohio.
He said adolescents should sit down for 15 minutes after getting a shot, as also advised by health officials.
"If they do fall and hit their head it can have consequences, so it's not something to be ignored," added Brady, who was not involved in the new work and has no ties to HPV vaccine makers.
Overall, he said the study didn't bring up any unexpected concerns.
"The combination of a vaccine that is working and is safe should make people feel comfortable," Brady added.
Gardasil is expected to prevent more than 90 percent of genital warts and between 60 and 70 percent of cervical cancers, according to Dr. Christopher Harrison of Children's Mercy Hospitals and Clinics in Kansas City, Missouri.
"The risk benefit here is clearly and resoundingly in favor of the vaccine being much more beneficial than risky," said Harrison, who was not linked to the new study and has not had any relationship to Merck for the past three years.
Archives of Pediatrics & Adolescent Medicine, online October 1, 2012.
- All Categories
- Academic Outreach
- Continuing & Professional Development
- Distance Learning
- Summer Sessions
- Winter Term
- Career & Workforce Development
- Lifelong Learning
- Society for Lifelong Learning
- WKU On Demand
- Study Away
- Faculty-Led Study Abroad
- Center for Faculty Development
- Cohort Programs
- Dual Credit
- Event & Training Services
- All Categories
- March 2016 ICYMI
- CHHS October 2011 E-Newsletter
- CHHS November 2011 E-Newsletter
- CHHS December 2011 E-Newsletter
- CHHS January 2012 E-Newsletter
- CHHS February 2012 E-Newsletter
- CHHS March 2012 E-Newsletter
- CHHS April 2012 E-Newsletter
- CHHS May 2012 E-Newsletter
- CHHS June 2012 E-Newsletter
- CHHS July 2012 E-Newsletter
- CHHS August 2012 E-Newsletter
- CHHS September 2012 E-Newsletter
- CHHS October 2012 E-Newsletter
- April 2016 ICYMI
- CHHS November 2012 E-Newsletter
- CHHS December 2012 E-Newsletter
- CHHS January 2013 E-Newsletter
- CHHS February 2013 E-Newsletter
- CHHS March 2013 E-Newsletter
- CHHS April 2013 E-Newsletter
- JUNE 2016 ICYMI
- CHHS May/June 2013 E-Newsletter
- CHHS July 2013 E-Newsletter
- Archived CHHS News
- CHHS October 2013 E-Newsletter
- CHHS November 2013 E-Newsletter
- CHHS December 2013 E-Newsletter
- CHHS February 2014 E-Newsletter
- CHHS November 2014 E-Newsletter
- CHHS May 2014 E-Newsletter
- CHHS April 2014 E-Newsletter
- CHHS June 2014 E-Newsletter
- CHHS July 2014 E-Newsletter
- CHHS December 2014 E-Newsletter
- CHHS August 2014 E-Newsletter
- CHHS September 2014 E-Newsletter
- CHHS October 2014 E-Newsletter
- CHHS January 2015 E-Newsletter
- CHHS February 2015 E-Newsletter
- CHHS May 2015 E-Newsletter
- CHHS July 2015 E-Newsletter
- CHHS August 2015 E-Newsletter
- CHHS September 2015 E-Newsletter
- CHHS November 2015 E-Newsletter
- CHHS October 2015 E-Newsletter
- December 2015 ICYMI
- January 2016 ICYMI
- MAY 2016 ICYMI
- February 2016 ICYMI
- CHHS July 2016 E-Newsletter
- CHHS August 2016 E-Newsletter
- CHHS September 2016 E-Newsletter
- CHHS October 2016 E-Newsletter
- CHHS November 2016 E-Newsletter
- CHHS December 2016 E-Newsletter
- CHHS January 2017 E-Newsletter
- CHHS February 2017 E-Newsletter
- CHHS March 2017 E-Newsletter
- CHHS April 2017 E-Newsletter
- CHHS September 2011 E-Newsletter
- CHHS August 2011 E-Newsletter
- CHHS July 2011 E-Newsletter
- CHHS June 2011 E-Newsletter
- CHHS May 2011 E-Newsletter
WKU student Emily Peck of Russell Springs recently was awarded a Study Abroad Grant worth $1,000 from The Honor Society of Phi Kappa Phi—the nation's oldest and most selective collegiate honor society for all academic disciplines.
The NBCC Foundation, an affiliate of the National Board for Certified Counselors (NBCC), recently selected WKU graduate student Holly C. Osterman of Bowling Green for the NBCC Minority Fellowship Program-Addictions Counselors.
A team from The Gatton Academy won the U.S. Department of Energy's (DOE) West Kentucky Regional Science Bowl on February 17 and advanced to the 2017 National Science Bowl in Washington, D.C.
After years of traditional recycling of keys, Access Control at WKU has found an innovative way to reuse the keys. Earlier this semester, the Architectural and Manufacturing Sciences Department melted 300 pounds of keys for students to use in class.
The 2017-2018 Cultural Enhancement Series Committee has announced its season lineup for the academic year beginning this fall.
Note: documents in Portable Document Format (PDF) require Adobe Acrobat Reader 5.0 or higher to view,
download Adobe Acrobat Reader.
Note: documents in Excel format (XLS) require Microsoft Viewer,
Note: documents in Word format (DOC) require Microsoft Viewer,
Note: documents in Powerpoint format (PPT) require Microsoft Viewer,
Note: documents in Quicktime Movie format [MOV] require Apple Quicktime,