Ajay Srivastava, Ph.D. University of Alberta
Office: TCCW 351
Biol 120: Biological Concepts: Cell Metabolism and Genetics
Biol 327: Genetics
Biol 440: Developmental Genetics
Research in my lab takes advantage of the sophisticated genetic tools available in the model organism Drosophila to better understand and dissect the underlying mechanisms of normal development and disease. We are particularly interested in understanding the contributions of Extracellular Matrix to normal development and tumorigenesis. Development of Drosophila wing is another area of my labs’ interest as this is an excellent model for organogenesis where various events that give rise to an adult structure can be studied. Several projects spanning the domain of our interest are available for motivated students. I welcome enquiries!
Postdoctoral (Developmental Genetics and Molecular Oncology), 2009: Yale University, New Haven, CT
Ph.D. (Molecular Biology and Genetics), 2003: University of Alberta, Edmonton, Canada
Gillian E. Jones and Ajay Srivastava. Understanding Lunasin’s Biology and Potential as a Cancer Therapeutic by utilizing Drosophila Genetics. Experimental Biology and Medicine 2014; 239: 519–528. DOI: 10.1177/1535370214522180.
Srivastava, A. A Protocol for Genetic Induction and Visualization of Benign and Invasive Tumors in Cephalic Complexes of Drosophila melanogaster. J. Vis. Exp. (79), e50624, doi:10.3791/50624 (2013).
Ajay Srivastava, Jose Carlos Pastor-Pareja, Tatsushi Igaki, Raymond Pagliarini and Tian Xu. Basement membrane remodeling is essential for Drosophila disc eversion and tumor invasion. Proceedings of the National Academy of Sciences, USA. 2007 Feb 20; 104(8):2721-6. Epub 2007 Feb 14.
Garg A, Srivastava A, Davis MM, O'Keefe S, Chow L, Bell JB. Antagonizing Scalloped with a Novel Vestigial Construct Reveals an Important role for Scalloped in Leg, Eye and Optic Lobe Development of Drosophila melanogaster. Genetics 2007 Feb;175(2):659-69. Epub 2006 Nov 16.
Srivastava A, Simmonds AJ, Garg A, Fossheim L,Campbell SD, Bell JB. Molecular and functional analysis of scalloped lethal alleles in Drosophila melanogaster. Genetics 2004, 166(4):1833-43.
MacKay JO, Soanes KH, Srivastava A, Simmonds AJ, Brook WJ, Bell JB. An in vivo analysis of the vestigial gene in Drosophila melanogaster confirms domains required for VG function. Genetics 2003, 163-4; 1365-73.
Srivastava A, Bell JB. Further developmental roles of the vestigial / scalloped transcription complex during wing development in Drosophila melanogaster. Mechanisms of Development 2003, 120(5); 587-96.
Srivastava A, Heise C, Garg A, Bell JB. The relationship between the dominant Additional vein mutant in Drosophila melanogaster and engrailed. Genome 2002, 45; 1077-1082.
Srivastava A, MacKay JO, Bell JB. A Vestigial:Scalloped TEA domain chimera rescues the wing phenotype of a scalloped mutation in Drosophila melanogaster. Genesis 2002, 33(1); 40-47.