New Targeted Drug Helps Smokers Quit
Date: Friday, March 18th, 2011
|Return to Archive|
"We're working on developing a CYP2A6 inhibitor, a targeted drug that would only be effective in specific parts of the body. Thankfully, we have a very clear picture of the structure of CYP2A6, and we'll be able to use computer-aided modelling methods to design molecules that will bind specifically to the target without disturbing other functions in the body. We've now finished our four-year project and have discovered several molecules of an until-now-unknown structure. Along the way, we've gained new insights into how the molecules bind to the active centre of the CYP2A6 enzyme. However, it'll take a good while -- and money -- before these molecules can be developed into a targeted drug," says Hannu Raunio, the principal investigator of the research project and Professor of Pharmacology at the University of Eastern Finland.
Traditional anti-smoking therapy has long been focused on smoking cessation. At present, there are a wide variety of treatments available to help smokers quit. Nicotine, buproprion and varenicline are among the most common drugs used in the treatment of smoking addiction. The idea behind pharmaceutical nicotine products is to relieve and prevent withdrawal symptoms so as to pave the way for smoking cessation. However, such forms of treatment are often unsuccessful, which has led to suggestions that new methods are needed, methods that would help in smoking reduction. It is this type of targeted drug that Raunio's project is developing.
12/12 and 12/13
Saturday, December 14th
New numbers out from the Centers for Disease Control and Prevention reveal that fewer women in the United States are having children.
How does one ditch a dependence on soda? Here are five tips for kicking your soda habit for good.
Are artificial sweeteners used in soft drinks and foods safe? Will they make us fat? How much is too much? Science doesn't have all the answers yet, but researchers have some clues.
Speed Limit Reduced on Normal and State Streets