Western Kentucky University

WKU Health Services : Health Services News

Stress experienced by men alters sperm and affects children

Stress as a pre-adolescent or adult leaves a lasting impression on a dad's sperm that gives his kids a blunted reaction to stress, U.S. researchers say.

Study leader Tracy L. Bale of the Perelman School of Medicine and the School of Veterinary Medicine at the University of Pennsylvania in Philadelphia said the findings point to a never-before-seen link to stress-related diseases such as anxiety and depression passed from father to child.

The study involved male mice exposed to six weeks of chronic stress, before breeding, either throughout puberty or only in adulthood. Examples of stress include sudden move to another cage, predator odor such as fox urine, noise, or a foreign object in the cage.

Male mice are ideal for such an experiment because they do not participate in offspring rearing, meaning any external factors outside of germ-cell formation are essentially eliminated, Bale said.

The study, published in the Journal of Neuroscience, found offspring from paternal stress groups displayed significantly blunted levels of the stress hormone corticosterone -- in humans, it's cortisol -- in response to stress.

This stress pathway dysregulation -- when reactivity to stress is either heightened or reduced -- is a sign an organism doesn't have the ability to respond appropriately to a changing environment and as a result, their stress response becomes irregular, which can lead to stress-related disorders, Bale said.

"It didn't matter if dads were going through puberty or in adulthood when stressed before they mated," Bale said in a statement. "We've shown here for the first time that stress can produce long-term changes to sperm that reprogram the offspring hypothalamic-pituitary-adrenal axis, a region of the brain that governs responses to stress."



Original link: http://www.upi.com/Health_News/2013/06/14/Stress-experienced-by-men-alters-sperm-and-affects-children/UPI-52111371257322/#ixzz2WTojYY1I

Categories
Latest Health News
Questions and Answers on Ebola

The current Ebola outbreak is centered on three countries in West Africa: Liberia, Guinea, Sierra Leone, although there is the potential for further spread to neighboring African countries.

Ebola Virus Is Outpacing Efforts to Control It, World Health Body Warns

In an ominous warning as fatalities mounted in West Africa from the worst known outbreak of the Ebola virus, the head of the World Health Organization said on Friday that the disease was moving faster than efforts to curb it.

Pathogens On A Plane: How To Stay Healthy In Flight

From Ebola in West Africa to chikungunya in the Caribbean, the world has had plenty of strange and scary outbreaks this year. Some pathogens have even landed in the U.S. Just a few months ago, two men boarded planes in Saudi Arabia and brought a from

Featured Articles
5 Ways to Drop Your Soda Habit

How does one ditch a dependence on soda? Here are five tips for kicking your soda habit for good.

Real or fake sugar: Does it matter?

Are artificial sweeteners used in soft drinks and foods safe? Will they make us fat? How much is too much? Science doesn't have all the answers yet, but researchers have some clues.

List of 'Salty Six' Foods May Surprise You
 Last Modified 7/22/13