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Western Kentucky University
EMERGENCY ALERT SYSTEM:

WKU WEATHER ALERT:

WKU offices in Bowling Green will open at 10 a.m. Friday. Classes Friday remain canceled and campuses in Glasgow, Owensboro and Elizabethtown/Ft. Knox remain closed Friday. Saturday classes in Bowling Green will proceed as scheduled. Here is a link to the University’s attendance policy during adverse weather conditions. Use caution and watch for slick spots on roads and walks. 

Residence Halls remain open until noon Saturday. Bemis & Barnes have space for those who need to stay longer. Visit WKU Housing & Residence Life for more information.

The high school regional basketball tournament games scheduled for Wednesday night were canceled. Games will be rescheduled for Friday/Saturday. Follow WKU News for the latest updates. #WKUAlert

Research Projects

Photograph: Srivastava Lab Presentation, 2011


REU Project 14—Understanding the contributions of extracellular matrix to normal development, tumorigenesis and metastasis using Drosophila genetics—Dr. Ajay Srivastava, Biology Department


Throughout development, tissues and organs are organized from diverse pools of cells. During this organization of tissues and organs the cells display features of proliferation, apoptosis, migratory and invasive behavior. These behaviors are also observed during the development and progression of tumor cells from benign to metastatic. Despite the involvement of these behaviors in normal development and cancer, the underlying mechanisms are not clearly understood. Research in my lab focuses on understanding the role of extracellular matrix (ECM), proteases and protease like molecules in normal development and tumorigenesis/metastasis using Drosophila genetics. We are particularly interested in understanding the contributions to tumorigenesis of a specialized form of ECM called basement membrane (BM) as this structure must be degraded during tissue remodeling and tumor metastasis. A better understanding of the ECM’s contribution to tumor development and metastasis could thus help in more effective drug design against cancer.


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 Last Modified 9/25/14